After celebrating Doug's upcoming wedding in a cut rate hotel in Laughlin, NV, hungover guys Bradley, Ed and Zach wake up in a futuristic dystopia, having lost their pal, Doug. With the help of Effing and Justmitch, the trio's loyal advisers, the gang must now prepare to battle their way through the pop culture districts of The Hungover Games including The Real Housewives of District 8 and Teddy from The Puppet District.

Cheech & Chong are invited to a celebrity party/festival in Amsterdam. When they get there, however, it turns out that the guy who invited them has taken off with all the money, and the rest of the hosts have a VERY limited budget. They are actually expecting Burt Reynolds and Dolly Parton, so our heroes gets to be Mr. Burt and Mr. Dolly. We follow them around Amsterdam, at their hotel, (still) smokin' joints and doing shows.